SimpleMail

SimpleMail is the easiest e-mail client there is! SimpleMail uses UAP (Unwanted Access Protection) exclusively to SimpleMail that automatically protects you from viruses in e-mails, malicious code in e-mails, and even pictures in spam that my be offensive in content. SimpleMail is compatible with many anti-virus programs, including:

Norton AntiVirus
McAfee VirusScan
Panda Tituanium AntiVirus
AVG AntiVirus (free and professional)
avast! AntiVirus (free and professional)

Normally, you can disable your e-mail protection in your anti-virus, because the UAP technology built in eliminates the need to keep the e-mail protection on.